![]() ![]() This design has been instrumental in advancing our understanding of the neural mechanisms underlying the impact of emotion on The memory-related brain activity that is susceptible to modulation by emotion from activity in brain regions susceptible to emotion modulation during This experimental protocol allows investigation of the neural correlates of the memory-enhancing effect of emotion, by specifically separating MTL particularly target areas in the prefrontal cortex (PFC), that are differentially involved in emotional vs. Investigation of brain regions outside of the source memory 19), or the type of retrieval task (recollection- vs. neutral memory 11), the type of memory being studied Investigations targeting MTL activity allow identification of functionalĭissociations, which are linked to the emotional content of stimuli (emotional vs. The modulatory effect of emotion on memory-related activity can be seen in areas showing greater ES / Dm or RSĪctivity for emotional than for neutral stimuli (see Figure 2). Individual and group-level statistical analyses involve comparisons of encoding/retrieval brain activity based If data are not smoothed and normalized (see 11). Normalization, and smoothing (8 mm 3 Kernel), but if analyses involve anatomically defined regions of interest (ROIs), increased spatial specificity is obtained Pre-processing typically involves: quality assurance, image alignment, motion correction, co-registration, Matlab-based tools were used for data analysis. Statistical Parametric Mapping (SPM: ( ) in combination with in-house This protocol can be used in healthy subjects 8-15, as well as in clinical patients where there are alterations in the neural correlates of emotion perceptionĪnd biases in remembering emotional events, such as those suffering from depression and post-traumatic stress disorder (PTSD) 16, 17. SMP allows identification of brain regions whose activity is susceptible to emotional modulation of both general/perceptual and memory-specific processing. ![]() Moreover, in the context of investigating the impact of emotional stimuli, An important feature of the SMP is that it allows separation of brain activity specificallyĪssociated with memory from more general activity associated with perception. Here, we describe a protocol that allows investigation of the neural correlates of the memory-enhancing effect of emotion using the SMP in conjunction withĮvent-related functional magnetic resonance imaging (fMRI). ![]() Neural correlates of non-emotional memories 3, and more recently we and others also applied it successfully to studies of emotional memory (reviewed in 4, 5-7). This method was originally used to investigate the Investigation of the memory-enhancing effect of emotion is the so-called subsequent memory paradigm (SMP). A method that has proven particularly influential in the To understand the neural mechanisms underlying this enhancing effect of emotion on memory. One goal of cognitive and affective neuroscientists is Emotional events tend to be better remembered than non-emotional events 1,2. ![]()
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